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Anti-Aging
05/31/2009

Q:  Anti-Aging medicine is the newest clinical medical specialty offered to physicians.  Human medicine is moving from a disease-based model to a preventive, proactive approach.  Shouldn’t veterinarians move in this direction as well?A:  The fact is movement is already occurring.  In recent years, advances in veterinary medicine have nearly doubled the lifespans of our pets.  Many veterinarians have shifted towards wellness protocols that get our pets into their offices two, three or even four times a year.  More visits mean more chances to find small issues before they become big problems!  But, just seeing your veterinarian more often is only part of the solution.When scientists unraveled the genetic code of dogs, they discovered humans and their canine counterparts share similar mechanisms relative to aging.  As we grow older, adverse changes in our cells increase the risk of death.   About a third of these changes are genetic in nature.  Most, however, are due to lifestyle and environmental factors.As systems slow down, cells deteriorate faster than the body can repair them, leading to a decline in function and changes in appearance.  The American Academy of Anti-Aging Medicine states that up to 90% of diseases are due to the degenerative process associated with aging.  So, earlier intervention by veterinarians might provide your pet with a longer, happier life.Currently, one aging theory has become almost universally accepted.  The theory states that cells accumulate damage from the presence of molecules with an unpaired electron, or free radical.  This cellular damage is cumulative and leads to a loss of functionality and death.  By finding ways to reduce the chaos caused by free radicals, scientists hope to lengthen the average lifespan.Some experts point towards antioxidants as the answer to free radical damage.   Antioxidants slow or even prevent the changes to cells by removing intermediary chemicals in the oxidation reaction of free radicals.  Once the intermediate steps are stopped, damage is reduced or avoided.   Antioxidants include compounds such as Vitamins C and E, beta carotene, retinol and melatonin.  Many fruits and vegetables contain high levels of these antioxidants. However, diet alone cannot provide the levels of antioxidants needed without seriously affecting caloric intake and causing obesity.  As with most things in life, more is not always better and in some cases, excess supplementation can result in adverse side effects.Antioxidant benefits are numerous, but the lack of standard dosages and clear research is a big concern.  More studies are sorely needed.   Despite this uncertainty, many pet food companies are marketing new lines of pet foods enhanced by antioxidants or touting “fresh fruits and vegetables” in their diets.  “Nutraceutical” supplements are also available that add antioxidants to the pet’s diet with promises of better health.  Another way to reduce the damage from free radicals is caloric restriction, or maintaining lean body weight.  Many different models, from mice and rats to fruit flies, have shown that reducing the amount of calories fed can increase life span.   Even dogs have benefitted.   One landmark study showed dogs kept lean using calorie restriction actually lived almost 2 years longer than their free fed counterparts.  Human studies show lower cholesterol, lower blood pressure and a lower body fat percentage as benefits of limiting caloric intake.So, what does this all mean to you and your pet?  Simply put, there is no magic bullet, but veterinary science continues to investigate novel therapies and ideas to help keep our pets with us even longer.  As with any medication or diet change, you should always discuss use of antioxidants or anti-aging therapy with your veterinarian.  Prevention, early disease detection and prompt intervention, combined with good nutrition, exercise and regular veterinary visits are the cornerstones of your pet’s good health.The Veterinary News Network contributed material for this week’s column.